The Science and Innovation Park of Ubon Ratchathani University began its operations in 2007 under the name "Ubon Ratchathani University Science Park Project." Initially, it received funding support from the National Science and Technology Development Agency (NSTDA) under the Ministry of Science and Technology, and the Office of the Higher Education Commission (OHEC) under the Ministry of Education. Subsequently, it received support from the Science Park Promotion Agency (SPA) under the Ministry of Science and Technology—now the Ministry of Higher Education, Science, Research and Innovation (MHESI). Its primary mission is to leverage the university's knowledge, innovations, equipment, personnel, and expertise in science and technology to enhance the capabilities of local business and private sectors. Additionally, the Park is tasked with fostering new entrepreneurs and promoting intellectual property management within the private sector.

The Science Park project was formally established as an enterprise unit named the "Science and Innovation Park of Ubon Ratchathani University." The establishment was announced on May 27, 2026, with effect from June 1, 2026, onwards. It operates under the supervision and governance of the State Enterprise Policy Committee, with the Science and Innovation Park Executive Committee responsible for overseeing its operations.